Regulation of the Drosophila Imd pathway by signaling amyloids

Insect Biochem Mol Biol. 2019 May:108:16-23. doi: 10.1016/j.ibmb.2019.03.003. Epub 2019 Mar 9.

Abstract

Fruit flies elicit effective defense responses against numerous microbes. The responses against Gram-negative bacteria are mediated by the Imd pathway, an evolutionarily conserved NF-κB pathway recognizing meso-diaminopimelic acid (DAP)-type peptidoglycan from bacterial cell walls. Several reviews already provide a detailed view of ligand recognition and signal transduction during Imd signaling, but the formation and regulation of the signaling complex immediately downstream of the peptidoglycan-sensing receptors is still elusive. In this review, we focus on the formation of the Imd amyloidal signaling center and post-translational modifications in the assembly and disassembly of the Imd signaling complex.

Keywords: Drosophila immunity; Functional amyloid; Imd signaling.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amyloid / immunology
  • Amyloid / metabolism*
  • Animals
  • Drosophila / immunology
  • Drosophila / metabolism*
  • Drosophila Proteins / metabolism
  • Immunity, Innate
  • NF-kappa B / metabolism*
  • Protein Processing, Post-Translational
  • Receptors, Cell Surface / metabolism
  • Signal Transduction

Substances

  • Amyloid
  • Drosophila Proteins
  • NF-kappa B
  • Receptors, Cell Surface
  • peptidoglycan receptor