SLAM-ing the brakes on iNKT cell selection

Shankar S Iyer; Yu-Hwa Huang; Richard S Blumberg

doi:10.1038/s41590-019-0355-8

SLAM-ing the brakes on iNKT cell selection

Nat Immunol. 2019 Apr;20(4):378-379. doi: 10.1038/s41590-019-0355-8.

Authors

Shankar S Iyer¹, Yu-Hwa Huang², Richard S Blumberg³

Affiliations

¹ Division of Gastroenterology, Hepatology and Endoscopy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. ssiyer@bwh.havard.edu.
² Division of Gastroenterology, Hepatology and Endoscopy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
³ Division of Gastroenterology, Hepatology and Endoscopy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. rblumberg@bwh.harvard.edu.

Abstract

Members of the SLAM family of receptors promote the progression of invariant natural killer T cells through the thymic maturation process and facilitate proper host responses to exogenous lipid antigen through the recruitment and activity of SAP–Fyn and SHP-1, respectively.

Publication types

Comment

MeSH terms

Natural Killer T-Cells*
Receptors, Antigen, T-Cell
Signal Transduction
Signaling Lymphocytic Activation Molecule Family
Signaling Lymphocytic Activation Molecule Family Member 1

Substances

Receptors, Antigen, T-Cell
Signaling Lymphocytic Activation Molecule Family
Signaling Lymphocytic Activation Molecule Family Member 1

Abstract

Publication types

MeSH terms

Substances

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