Marine n-3 Polyunsaturated Fatty Acid Supplementation and Quality of Life After Kidney Transplant

W Aasebø; M Svensson; T Jenssen; I A Eide

doi:10.1016/j.transproceed.2019.01.067

Marine n-3 Polyunsaturated Fatty Acid Supplementation and Quality of Life After Kidney Transplant

Transplant Proc. 2019 Mar;51(2):466-469. doi: 10.1016/j.transproceed.2019.01.067. Epub 2019 Jan 28.

Authors

W Aasebø¹, M Svensson², T Jenssen³, I A Eide⁴

Affiliations

¹ Department of Renal Medicine, Akershus University Hospital, Lørenskog, Norway. Electronic address: wiaa@ahus.no.
² Department of Renal Medicine, Akershus University Hospital, Lørenskog, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
³ Department of Transplantation Medicine, Oslo University Hospital, Oslo, Norway; Metabolic and Renal Research Group, UiT The Arctic University of Norway, Tromsø, Norway.
⁴ Department of Renal Medicine, Akershus University Hospital, Lørenskog, Norway; Department of Transplantation Medicine, Oslo University Hospital, Oslo, Norway.

PMID: 30879569
DOI: 10.1016/j.transproceed.2019.01.067

Abstract

Marine n-3 polyunsaturated fatty acids (PUFAs) may improve cardiovascular, renal, and mental health. No previous trial has investigated the effects of marine n-3 PUFA supplementation on quality of life (QoL) indices after renal transplant.

Methods: In this trial, 132 renal transplant recipients were randomized to receive daily either 2.6 g of marine n-3 PUFAs or an equivalent dose of olive oil (controls) on top of standard care for 44 weeks. We used a Short Form 36 (SF-36) questionnaire at baseline (8 weeks post transplant) and at the end of the study (1 year after transplant) to assess QoL. Results were expressed as net change (Δ) in SF-36 individual and composite mental and physical scores during follow-up.

Results: We found no improvement of Δ SF-36 individual or composite scores after marine n-3 PUFA supplementation compared with controls. In per-protocol analysis, patients who received marine n-3 PUFAs had a Δ emotional role function (mean, 17% [SD, 50%] vs mean, 3% [SD, 37%]; P = .11). In addition, plasma marine n-3 PUFA levels showed a weak but statistically significant correlation with Δ composite mental function score (r = .18; P = .04).

Conclusion: Marine n-3 PUFA supplementation did not improve QoL after renal transplant.

Publication types

Randomized Controlled Trial

MeSH terms

Adult
Aged
Dietary Supplements*
Fatty Acids, Omega-3 / administration & dosage*
Female
Humans
Kidney Transplantation* / psychology
Male
Middle Aged
Quality of Life*
Surveys and Questionnaires
Transplant Recipients / psychology

Substances

Fatty Acids, Omega-3