Aquaporins in female specific cancers

Prameswari Kasa; Batoul Farran; Ganji Lakshmi Vara Prasad; Ganji Purnachandra Nagaraju

doi:10.1016/j.gene.2019.03.032

Aquaporins in female specific cancers

Gene. 2019 Jun 5:700:60-64. doi: 10.1016/j.gene.2019.03.032. Epub 2019 Mar 18.

Authors

Prameswari Kasa¹, Batoul Farran², Ganji Lakshmi Vara Prasad¹, Ganji Purnachandra Nagaraju³

Affiliations

¹ Dr. LV Prasad Diagnostics and Research Laboratory, Khairtabad, Hyderabad, Telangana 500004, India.
² Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA.
³ Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA. Electronic address: pganji@emory.edu.

PMID: 30898710
DOI: 10.1016/j.gene.2019.03.032

Abstract

Aquaporins (AQPs) are hydrophobic integral trans-membrane channel proteins implicated in cellular proliferation and water transport in various cancers. They compose a family of 13 different isoforms (25-34 kDa) in mammals that have been identified to date. These AQPs exhibit a unique pattern of tissue expression. Though they can be found in most tissues, they are mostly active in endothelial and epithelial tissues. In this review, the AQPs associated with female-specific cancers are comprehensively explored and their significant features are analysed. Recent findings revealing their role in female-specific carcinogenesis, especially cervical, ovarian, uterine/endometrial, and breast, will be also discussed.

Keywords: Aquaporins; Breast cancer; Cervical cancer; Endometrial cancer; Ovarian cancer.

Publication types

Review

MeSH terms

Aquaporins / metabolism*
Breast Neoplasms / metabolism*
Female
Gene Expression Regulation, Neoplastic
Genital Neoplasms, Female / metabolism*
Humans
Multigene Family
Organ Specificity

Substances

Aquaporins