Genome-Wide Association Study in Irradiated Childhood Cancer Survivors Identifies HTR2A for Subsequent Basal Cell Carcinoma

Yadav Sapkota; Lucie M Turcotte; Matthew J Ehrhardt; Rebecca M Howell; Michael A Arnold; Carmen L Wilson; Wendy Leisenring; Zhaoming Wang; Joshua Sampson; Casey L Dagnall; Eric Karlins; Shengchao Alfred Li; Belynda D Hicks; Rita Weathers; Susan A Smith; Kyla Shelton; Qi Liu; Margaret A Tucker; Stephen J Chanock; Jinghui Zhang; Melissa M Hudson; Joseph P Neglia; Gregory T Armstrong; Leslie L Robison; Lindsay M Morton; Smita Bhatia; Yutaka Yasui

doi:10.1016/j.jid.2019.02.029

Genome-Wide Association Study in Irradiated Childhood Cancer Survivors Identifies HTR2A for Subsequent Basal Cell Carcinoma

J Invest Dermatol. 2019 Sep;139(9):2042-2045.e8. doi: 10.1016/j.jid.2019.02.029. Epub 2019 Mar 22.

Authors

Yadav Sapkota¹, Lucie M Turcotte², Matthew J Ehrhardt³, Rebecca M Howell⁴, Michael A Arnold⁵, Carmen L Wilson⁶, Wendy Leisenring⁷, Zhaoming Wang⁸, Joshua Sampson⁹, Casey L Dagnall¹⁰, Eric Karlins¹⁰, Shengchao Alfred Li¹⁰, Belynda D Hicks¹⁰, Rita Weathers⁴, Susan A Smith⁴, Kyla Shelton⁶, Qi Liu¹¹, Margaret A Tucker⁹, Stephen J Chanock⁹, Jinghui Zhang⁸, Melissa M Hudson³, Joseph P Neglia², Gregory T Armstrong³, Leslie L Robison⁶, Lindsay M Morton⁹, Smita Bhatia¹², Yutaka Yasui¹³

Affiliations

¹ Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee, USA. Electronic address: Yadav.Sapkota@stjude.org.
² Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
³ Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee, USA; Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
⁴ Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
⁵ Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital, Columbus, Ohio, USA; Department of Pathology, The Ohio State University, Columbus, Ohio, USA.
⁶ Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
⁷ Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
⁸ Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
⁹ Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
¹⁰ Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA; Cancer Genomics Research Laboratory, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.
¹¹ School of Public Health, University of Alberta, Alberta, Canada.
¹² Institute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham, Alabama, USA.
¹³ Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee, USA; School of Public Health, University of Alberta, Alberta, Canada.

No abstract available

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Cancer Survivors / statistics & numerical data*
Carcinoma, Basal Cell / epidemiology
Carcinoma, Basal Cell / genetics*
Carcinoma, Basal Cell / pathology
Child
Child, Preschool
Female
Follow-Up Studies
Genetic Loci / genetics
Genome-Wide Association Study
Humans
Linkage Disequilibrium
Male
Middle Aged
Neoplasms / mortality
Neoplasms / radiotherapy*
Neoplasms, Radiation-Induced / epidemiology
Neoplasms, Radiation-Induced / genetics*
Neoplasms, Radiation-Induced / pathology
Polymorphism, Single Nucleotide
Prospective Studies
Receptor, Serotonin, 5-HT2A / genetics*
Retrospective Studies
Skin / pathology
Skin / radiation effects
Skin Neoplasms / epidemiology
Skin Neoplasms / genetics*
Skin Neoplasms / pathology
Young Adult

Substances

HTR2A protein, human
Receptor, Serotonin, 5-HT2A

Publication types

MeSH terms

Substances

Grants and funding