Distinct resting state functional connectivity abnormalities in hoarding disorder and major depressive disorder

Hannah C Levy; Michael C Stevens; David C Glahn; Krishna Pancholi; David F Tolin

doi:10.1016/j.jpsychires.2019.03.022

Distinct resting state functional connectivity abnormalities in hoarding disorder and major depressive disorder

J Psychiatr Res. 2019 Jun:113:108-116. doi: 10.1016/j.jpsychires.2019.03.022. Epub 2019 Mar 26.

Authors

Hannah C Levy¹, Michael C Stevens², David C Glahn², Krishna Pancholi³, David F Tolin⁴

Affiliations

¹ Anxiety Disorders Center, Institute of Living/Hartford Hospital, 200 Retreat Avenue, Hartford, CT, 06106, USA. Electronic address: hannah.levy@hhchealth.org.
² Olin Neuropsychiatry Research Center, Institute of Living/Hartford Hospital, 400 Washington Street, Hartford, CT, 06106, USA; Department of Psychiatry, Yale University School of Medicine, 300 George Street, New Haven, CT, 06511, USA.
³ Olin Neuropsychiatry Research Center, Institute of Living/Hartford Hospital, 400 Washington Street, Hartford, CT, 06106, USA.
⁴ Anxiety Disorders Center, Institute of Living/Hartford Hospital, 200 Retreat Avenue, Hartford, CT, 06106, USA; Department of Psychiatry, Yale University School of Medicine, 300 George Street, New Haven, CT, 06511, USA.

Abstract

Emerging research suggests that hoarding disorder (HD) is associated with abnormal hemodynamic activity in frontal brain regions. Prior studies have not examined intrinsic network connectivity in HD during unstructured "resting state" fMRI. Furthermore, it remains unclear whether previously observed HD abnormalities might be better explained by the presence of other disorders frequently comorbid with HD, such as major depressive disorder (MDD). The current study compared resting state functional connectivity in HD-only patients (n = 17), MDD-only patients (n = 8), patients with co-occurring HD and MDD (n = 10), and healthy control participants (n = 18). Using independent component analysis, we found that HD-only patients exhibited lower functional connectivity in a "task positive" cognitive control network, compared to the other three groups. The HD group also had greater connectivity in regions of the "task negative" default mode network than did the other groups. Findings suggest that HD is associated with a unique neurobiological profile, and are discussed in terms of recent neurological and neuropsychological findings and models in HD and related disorders.

Keywords: Depression; Hoarding disorder; Resting state; fMRI.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Brain / physiopathology*
Brain Mapping / methods
Depressive Disorder, Major / physiopathology*
Female
Hoarding Disorder / physiopathology*
Humans
Magnetic Resonance Imaging / methods*
Male
Middle Aged
Rest

Abstract

Publication types

MeSH terms

Grants and funding