Management of genetically determined colorectal cancer

S K Clark

doi:10.1016/j.surge.2019.03.003

Management of genetically determined colorectal cancer

Surgeon. 2019 Jun;17(3):165-171. doi: 10.1016/j.surge.2019.03.003. Epub 2019 Mar 29.

Author

S K Clark¹

Affiliation

¹ St. Mark's Hospital, Harrow, UK; Department of Surgery and Cancer, Imperial College, London, UK. Electronic address: s.clark8@nhs.net.

PMID: 30935877
DOI: 10.1016/j.surge.2019.03.003

Abstract

Surgeons are increasingly treating patients for colorectal cancer who are known to have a genetic predisposition to develop the disease; this may modify the surgical and oncological management of the patient. In this review the approach to the patient with colorectal cancer on a background of Lynch syndrome or familial adenomatous polyposis is explored.

Keywords: Colorectal cancer; Familial adenomatous polyposis; Lynch syndrome.

Publication types

Review

MeSH terms

Adenomatous Polyposis Coli / diagnosis
Adenomatous Polyposis Coli / genetics
Adenomatous Polyposis Coli / therapy*
Aftercare / methods
Clinical Decision-Making
Colorectal Neoplasms, Hereditary Nonpolyposis / diagnosis
Colorectal Neoplasms, Hereditary Nonpolyposis / genetics
Colorectal Neoplasms, Hereditary Nonpolyposis / therapy*
Combined Modality Therapy
Genetic Predisposition to Disease
Humans