Functional Cyclodextrin-Clicked Chiral Stationary Phases for Versatile Enantioseparations by HPLC

Jie Zhou; Jian Tang; Weihua Tang

doi:10.1007/978-1-4939-9438-0_8

Functional Cyclodextrin-Clicked Chiral Stationary Phases for Versatile Enantioseparations by HPLC

Methods Mol Biol. 2019:1985:147-157. doi: 10.1007/978-1-4939-9438-0_8.

Authors

Jie Zhou¹, Jian Tang¹, Weihua Tang²

Affiliations

¹ Key Laboratory of Soft Chemistry and Functional Materials, Ministry of Education, Nanjing University of Science and Technology, Nanjing, People's Republic of China.
² Key Laboratory of Soft Chemistry and Functional Materials, Ministry of Education, Nanjing University of Science and Technology, Nanjing, People's Republic of China. whtang@njust.edu.cn.

PMID: 31069733
DOI: 10.1007/978-1-4939-9438-0_8

Abstract

The urgent demand for pure biological and pharmaceutical enantiomers has brought together great efforts in developing chiral techniques. High-performance liquid chromatography employing chiral stationary phases (CSPs) has evolved as a powerful tool for both chiral analysis and manufacture of pure enantiomers. Herein, we describe a facile method to prepare a phenylcarbamate cyclodextrin (CD)-based CSPs via azide/alkyne click chemistry. The functionalities of CD rims are altered to mediate the enantioseparation performance in multimode high-performance liquid chromatography.

Keywords: Chiral separation; Chiral stationary phases; Click chemistry; Multimode; Phenylcarbamate cyclodextrin.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkynes / chemistry
Chromatography, High Pressure Liquid / methods*
Click Chemistry / methods*
Cyclodextrins / chemistry*
Phenylcarbamates / chemical synthesis
Phenylcarbamates / chemistry
Silica Gel / chemistry
Stereoisomerism

Substances

Alkynes
Cyclodextrins
Phenylcarbamates
Silica Gel