Antithymocyte globulin in the treatment of gold induced severe aplastic anemia

J Rheumatol. 1988 Jan;15(1):43-5.

Abstract

Severe aplastic anemia is the most serious complication of chrysotherapy. No treatment for this condition has been demonstrated effective. We report 3 patients with gold induced severe aplastic anemia treated with antithymocyte globulin. Complete marrow recovery was obtained in 1 case and a partial but satisfactory response in the other. All the patients remain alive without requiring blood transfusion after followup of longer than 16 months.

MeSH terms

  • Adult
  • Anemia, Aplastic / blood
  • Anemia, Aplastic / chemically induced
  • Anemia, Aplastic / therapy*
  • Antilymphocyte Serum / administration & dosage
  • Antilymphocyte Serum / therapeutic use*
  • Arthritis, Rheumatoid / drug therapy
  • Blood Cell Count
  • Female
  • Gold Sodium Thiomalate / adverse effects*
  • Humans
  • Male
  • Middle Aged
  • T-Lymphocytes / immunology*

Substances

  • Antilymphocyte Serum
  • Gold Sodium Thiomalate