Pharmacokinetics of thio-TEPA at two different doses

B Hagen; R A Walstad; O G Nilsen

doi:10.1007/BF00254246

Pharmacokinetics of thio-TEPA at two different doses

Cancer Chemother Pharmacol. 1988;22(4):356-8. doi: 10.1007/BF00254246.

Authors

B Hagen¹, R A Walstad, O G Nilsen

Affiliation

¹ Department of Pharmacology and Toxicology, University of Trondheim, Norway.

PMID: 3139316
DOI: 10.1007/BF00254246

Abstract

Thio-TEPA pharmacokinetics were studied at doses of 20 mg and 30 mg in six patients treated for ovarian cancer. Considerable interindividual variation was encountered in its pharmacokinetics, which were dose-independent within the dose range studied and similar to those reported at far higher doses. Interindividual dosing of thio-TEPA based on an initial AUC estimation is suggested.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Aged, 80 and over
Algorithms
Female
Humans
Ovarian Neoplasms / drug therapy*
Thiotepa / administration & dosage
Thiotepa / pharmacokinetics*

Substances

Thiotepa