Efficacy and safety of methotrexate versus placebo as add-on therapy to H1 antihistamines for patients with difficult-to-treat chronic spontaneous urticaria: A randomized, controlled trial

Sophie Leducq; Mahtab Samimi; Claire Bernier; Angèle Soria; Emmanuelle Amsler; Delphine Staumont-Sallé; Germaine Gabison; Olivier Chosidow; Nathalie Bénéton; Corina Bara; Anne Grange-Prunier; Ewa Wierzbicka-Hainaut; Emilie Brenaut; Catherine Droitcourt; Nathalie Raison-Peyron; Hélène Bourgoin; Hélène Cornillier; Laurent Machet; Bruno Giraudeau; Agnès Caille; Annabel Maruani

doi:10.1016/j.jaad.2019.07.097

Efficacy and safety of methotrexate versus placebo as add-on therapy to H1 antihistamines for patients with difficult-to-treat chronic spontaneous urticaria: A randomized, controlled trial

J Am Acad Dermatol. 2020 Jan;82(1):240-243. doi: 10.1016/j.jaad.2019.07.097. Epub 2019 Aug 5.

Authors

Sophie Leducq¹, Mahtab Samimi², Claire Bernier³, Angèle Soria⁴, Emmanuelle Amsler⁴, Delphine Staumont-Sallé⁵, Germaine Gabison⁶, Olivier Chosidow⁶, Nathalie Bénéton⁷, Corina Bara⁷, Anne Grange-Prunier⁸, Ewa Wierzbicka-Hainaut⁹, Emilie Brenaut¹⁰, Catherine Droitcourt¹¹, Nathalie Raison-Peyron¹², Hélène Bourgoin¹³, Hélène Cornillier¹⁴, Laurent Machet¹⁴, Bruno Giraudeau¹⁵, Agnès Caille¹⁵, Annabel Maruani¹⁶

Affiliations

¹ Department of Dermatology, University Hospital of Tours, Tours, France; Clinical Investigation Center, INSERM CIC 1415, University Hospital of Tours, Tours, France; Université de Tours, Université de Nantes, INSERM U1246-SPHERE, France. Electronic address: soleducq@gmail.com.
² Department of Dermatology, University Hospital of Tours, Tours, France; ISP 1282 INRA, University of Tours, Tours, France.
³ Department of Dermatology, University Hospital Center of Nantes, Nantes, France.
⁴ Department of Dermatology and Allergology, Hospital Tenon, Paris, Assistance Publique Hopitaux de Paris, Sorbonne Université, Paris, France.
⁵ CHU Lille, Service de dermatologie et vénérologie, F-59000 Lille, France, Univ. Lille, Inserm U995 - LIRIC - Lille Inflammation Research International Center, F-59000 Lille, France.
⁶ Department of Dermatology, Assistance Publique Hôpitaux de Paris, Henri-Mondor Hospital, Créteil, France.
⁷ Department of Dermatology, Hospital Center of le Mans, le Mans, France.
⁸ Department of Dermatology, Reims University Hospital, University of Reims-Champagne-Ardenne, Reims, France.
⁹ Department of Dermatology, University Hospital of Poitiers, Poitiers, France.
¹⁰ Department of Dermatology, University Hospital of Brest, Brest, France.
¹¹ Department of Dermatology, University Hospital of Rennes, Rennes, France.
¹² Department of Dermatology, University Hospital of Montpellier, Montpellier, France.
¹³ Department of Pharmacy, University Hospital of Tours, Tours, France.
¹⁴ Department of Dermatology, University Hospital of Tours, Tours, France.
¹⁵ Clinical Investigation Center, INSERM CIC 1415, University Hospital of Tours, Tours, France; Université de Tours, Université de Nantes, INSERM U1246-SPHERE, France.
¹⁶ Department of Dermatology, University Hospital of Tours, Tours, France; Université de Tours, Université de Nantes, INSERM U1246-SPHERE, France.

PMID: 31394130
DOI: 10.1016/j.jaad.2019.07.097

No abstract available

Publication types

Comparative Study
Letter
Multicenter Study
Randomized Controlled Trial

MeSH terms

Adult
Chronic Urticaria / drug therapy*
Double-Blind Method
Drug Therapy, Combination
Female
Histamine H1 Antagonists / therapeutic use*
Humans
Immunosuppressive Agents / adverse effects
Immunosuppressive Agents / therapeutic use*
Male
Methotrexate / adverse effects
Methotrexate / therapeutic use*
Middle Aged
Quality of Life

Substances

Histamine H1 Antagonists
Immunosuppressive Agents
Methotrexate