Nickel-Catalyzed Chemoselective Acetalization of Aldehydes With Alcohols under Neutral Conditions

Murugan Subaramanian; Vinod G Landge; Akash Mondal; Virendrakumar Gupta; Ekambaram Balaraman

doi:10.1002/asia.201900908

Nickel-Catalyzed Chemoselective Acetalization of Aldehydes With Alcohols under Neutral Conditions

Chem Asian J. 2019 Dec 13;14(24):4557-4562. doi: 10.1002/asia.201900908. Epub 2019 Aug 23.

Authors

Murugan Subaramanian¹, Vinod G Landge¹, Akash Mondal¹, Virendrakumar Gupta², Ekambaram Balaraman¹

Affiliations

¹ Department of Chemistry, Indian Institute of Science Education and Research Tirupati (IISER-Tirupati), Tirupati-, 517507, India.
² Polymer Synthesis & Catalysis, Reliance Research &, Development Centre, Reliance Industries Limited, Ghansoli-, 400701, Navi Mumbai, India.

PMID: 31407487
DOI: 10.1002/asia.201900908

Abstract

A molecularly defined Ni^II -complex catalyzing the chemoselective acetalization of aldehydes with alcohols under neutral conditions is reported. The reaction is general, efficient and showed a wide substrate scope (including aliphatic aldehydes) as well as excellent functional group tolerance. Reusability of the present nickel catalyst is also demonstrated.

Keywords: acetalization; alcohols; aldehydes; homogeneous catalysis; nickel.

Grants and funding

CRG/2018/002480/OC/Science and Engineering Research Board