Successful Clinical Outcome of Vancomycin-induced Hemorrhagic Occlusive Retinal Vasculitis

Ocul Immunol Inflamm. 2021 May 19;29(4):762-765. doi: 10.1080/09273948.2019.1640881. Epub 2019 Aug 16.

Abstract

We present a case of a patient that experienced severe hemorrhagic occlusive retinal vasculitis secondary to injection of 1.0 mg/0.1 ml of intracameral vancomycin for endophthalmitis prophylaxis after an uneventful cataract surgery. The case is especially unique in that our patient ended up maintaining 20/25 vision with an ocular disease that is typically visually threatening. This may be due to the aggressive administration of periocular and oral steroids combined with scheduled anti-VEGF injections that were later transitioned into a treat and extend regimen.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Anti-Bacterial Agents / adverse effects*
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Antiviral Agents / therapeutic use
  • Benzophenones / therapeutic use
  • Bromobenzenes / therapeutic use
  • Cataract Extraction
  • Drug Combinations
  • Endophthalmitis / microbiology
  • Endophthalmitis / prevention & control
  • Eye Infections, Bacterial / microbiology
  • Eye Infections, Bacterial / prevention & control
  • Female
  • Fluorescein Angiography
  • Glucocorticoids / therapeutic use
  • Humans
  • Prednisone / therapeutic use
  • Retinal Hemorrhage / chemically induced
  • Retinal Hemorrhage / diagnosis
  • Retinal Hemorrhage / drug therapy*
  • Retinal Vasculitis / chemically induced
  • Retinal Vasculitis / diagnosis
  • Retinal Vasculitis / drug therapy*
  • Tomography, Optical Coherence
  • Valacyclovir / therapeutic use
  • Vancomycin / adverse effects*

Substances

  • Anti-Bacterial Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antiviral Agents
  • Benzophenones
  • Bromobenzenes
  • Drug Combinations
  • Glucocorticoids
  • Vancomycin
  • bromfenac
  • Valacyclovir
  • Prednisone