Postprandial changes in gene expression of cholesterol influx and efflux mediators after intake of SFA compared with n-6 PUFA in subjects with and without familial hypercholesterolaemia: secondary outcomes of a randomised controlled trial

Linn K L Øyri; Ingunn Narverud; Martin P Bogsrud; Patrik Hansson; Lena Leder; Marte G Byfuglien; Marit B Veierød; Magne Thoresen; Stine M Ulven; Kirsten B Holven

doi:10.1017/jns.2019.25

Postprandial changes in gene expression of cholesterol influx and efflux mediators after intake of SFA compared with n-6 PUFA in subjects with and without familial hypercholesterolaemia: secondary outcomes of a randomised controlled trial

J Nutr Sci. 2019 Aug 13:8:e27. doi: 10.1017/jns.2019.25. eCollection 2019.

Authors

Linn K L Øyri¹, Ingunn Narverud^{1

2}, Martin P Bogsrud^{2

3}, Patrik Hansson¹, Lena Leder⁴, Marte G Byfuglien⁴, Marit B Veierød⁵, Magne Thoresen⁵, Stine M Ulven¹, Kirsten B Holven^{1

2}

Affiliations

¹ Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Sognsvannsveien 9, 0372 Oslo, Norway.
² Norwegian National Advisory Unit on Familial Hypercholesterolemia, Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Aker Hospital, Building 6, 6th floor, Trondheimsveien 232, 0586 Oslo, Norway.
³ Unit for Cardiac and Cardiovascular Genetics, Oslo University Hospital, Kirkeveien 166, 0450 Oslo, Norway.
⁴ Mills AS, Sofienberggt. 19, 0558 Oslo, Norway.
⁵ Oslo Centre for Biostatistics and Epidemiology, Department of Biostatistics, Institute of Basic Medical Sciences, University of Oslo, Sognsvannsveien 9, 0372 Oslo, Norway.

Abstract

Keywords: CT, cycle threshold; FH, familial hypercholesterolaemia; Familial hypercholesterolaemia; Fat quality; Gene expression; LDL receptor; LDL-C, LDL-cholesterol; LDLR, LDL receptor; PBMC, peripheral blood mononuclear cells; Postprandial responses; SREBP, sterol regulatory element binding protein.

Publication types

Randomized Controlled Trial
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Cholesterol / blood*
Fatty Acids / blood
Female
Gene Expression*
Homeostasis
Humans
Hyperlipoproteinemia Type II / complications*
Male
Postprandial Period*
Receptors, LDL / genetics*
Young Adult

Substances

Fatty Acids
Receptors, LDL
Cholesterol