A Pungent and Painful Toxin

Dustin Green; Xinzhong Dong

doi:10.1016/j.cell.2019.08.016

A Pungent and Painful Toxin

Cell. 2019 Sep 5;178(6):1279-1281. doi: 10.1016/j.cell.2019.08.016. Epub 2019 Aug 29.

Authors

Dustin Green¹, Xinzhong Dong²

Affiliations

¹ The Solomon H. Snyder Department of Neuroscience, Department of Neurosurgery, Department of Dermatology, Center for Sensory Biology, Johns Hopkins University, School of Medicine, Baltimore, MD 21205. Electronic address: dgreen89@jhmi.edu.
² The Solomon H. Snyder Department of Neuroscience, Department of Neurosurgery, Department of Dermatology, Center for Sensory Biology, Johns Hopkins University, School of Medicine, Baltimore, MD 21205; Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205. Electronic address: xdong2@jhmi.edu.

PMID: 31474364
DOI: 10.1016/j.cell.2019.08.016

Abstract

In this issue of Cell, King et al. (2019) have discovered a cell penetrating peptide isolated from the venom of the Australian Black Rock scorpion that activates the TRPA1 receptor in a unique way to induce pain. Their findings offer new insights into how animals evolved venoms to target specific ion channel functions.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Animals
Australia
Pain
Peptides
Scorpion Venoms*
Scorpions*

Substances

Peptides
Scorpion Venoms

Abstract

Publication types

MeSH terms

Substances

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