A supramolecular sensor array for selective immunoglobulin deficiency analysis

Yang Liu; Adam D Gill; Yaokai Duan; Lizeth Perez; Richard J Hooley; Wenwan Zhong

doi:10.1039/c9cc06064b

A supramolecular sensor array for selective immunoglobulin deficiency analysis

Chem Commun (Camb). 2019 Sep 24;55(77):11563-11566. doi: 10.1039/c9cc06064b.

Authors

Yang Liu¹, Adam D Gill², Yaokai Duan³, Lizeth Perez³, Richard J Hooley⁴, Wenwan Zhong⁵

Affiliations

¹ University of California - Riverside, Environmental Toxicology Program, Riverside, CA 92521, USA. wenwan.zhong@ucr.edu.
² University of California - Riverside, Department of Biochemistry and Molecular Biology, Riverside, CA 92521, USA.
³ University of California - Riverside, Department of Chemistry, Riverside, CA 92521, USA. richard.hooley@ucr.edu.
⁴ University of California - Riverside, Department of Biochemistry and Molecular Biology, Riverside, CA 92521, USA and University of California - Riverside, Department of Chemistry, Riverside, CA 92521, USA. richard.hooley@ucr.edu.
⁵ University of California - Riverside, Environmental Toxicology Program, Riverside, CA 92521, USA. wenwan.zhong@ucr.edu and University of California - Riverside, Department of Chemistry, Riverside, CA 92521, USA. richard.hooley@ucr.edu.

PMID: 31495837
DOI: 10.1039/c9cc06064b

Abstract

A host-guest based fluorescence sensor array can sense small differences in protein structure. The combination of three cavitand hosts and two fluorophores to form a 4-component array is sufficient to fully discriminate five structurally similar Ig protein isotypes. The array can be applied to recognize Ig deficiencies in serum, when combined with a Protein L-based extraction process, allowing analysis of immunodeficiency in a simpler, lower cost manner than tests that require multiple specific antibodies.