Perspective: the essential role of NMR in the discovery and characterization of intrinsically disordered proteins

H Jane Dyson; Peter E Wright

doi:10.1007/s10858-019-00280-2

Perspective: the essential role of NMR in the discovery and characterization of intrinsically disordered proteins

J Biomol NMR. 2019 Dec;73(12):651-659. doi: 10.1007/s10858-019-00280-2. Epub 2019 Oct 15.

Authors

H Jane Dyson¹, Peter E Wright²

Affiliations

¹ Department of Integrative Structural and Computational Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA. dyson@scripps.edu.
² Department of Integrative Structural and Computational Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA. wright@scripps.edu.

Abstract

The 2019 ISMAR Prize recognized NMR studies of disordered proteins. Here we provide a highly personal perspective on the discovery of intrinsically disordered proteins and the development and application of NMR methods to characterize their conformational ensembles, dynamics, and interactions.

Keywords: Immunogenic peptides; Intrinsically disordered proteins; Protein folding; Relaxation dispersion.

Publication types

Review

MeSH terms

Animals
Awards and Prizes
Humans
Intrinsically Disordered Proteins / chemistry*
Molecular Dynamics Simulation
Nuclear Magnetic Resonance, Biomolecular / methods*
Protein Binding
Protein Conformation

Substances

Intrinsically Disordered Proteins

Abstract

Publication types

MeSH terms

Substances

Grants and funding