Presumed antiphospholipid syndrome and thrombotic thrombocytopenic purpura: An infrequent association

Hallie Hanna Dolin; Mark Dziuba; Scott M Pappada; Thomas John Papadimos

doi:10.1002/ccr3.2416

Presumed antiphospholipid syndrome and thrombotic thrombocytopenic purpura: An infrequent association

Clin Case Rep. 2019 Sep 9;7(10):1984-1988. doi: 10.1002/ccr3.2416. eCollection 2019 Oct.

Authors

Hallie Hanna Dolin¹, Mark Dziuba², Scott M Pappada², Thomas John Papadimos^{1

2

3}

Affiliations

¹ Department of Medical Microbiology and Immunology University of Toledo College of Medicine and Life Sciences Toledo OH USA.
² Department of Anesthesiology University of Toledo College of Medicine and Life Sciences Toledo OH USA.
³ Department of Anesthesiology The Ohio State University Wexner Medical Center Columbus OH USA.

Abstract

Antiphospholipid syndrome (APS) is an autoimmune disease that demonstrates antiphospholipid antibodies that cause hypercoagulability and leads to venous and arterial thrombosis. Autoantibodies to a disintegrin-like and metalloprotease with thrombospondin type I motif, member 13 (ADAMTS 13) play a role in the microthrombosis of thrombotic thrombocytopenic purpura in APS patients.

Keywords: ADAMTS13; antiphospholipid syndrome; disintegrin‐like and metalloprotease; thrombotic thrombocytopenic purpura.

Publication types

Case Reports