Sleep apnea and kidney transplant outcomes: findings from a 20-year (1997-2017) historical cohort study

Margaret M Lubas; J Catesby Ware; Mariana Szklo-Coxe

doi:10.1016/j.sleep.2019.05.014

Sleep apnea and kidney transplant outcomes: findings from a 20-year (1997-2017) historical cohort study

Sleep Med. 2019 Nov:63:151-158. doi: 10.1016/j.sleep.2019.05.014. Epub 2019 Jun 12.

Authors

Margaret M Lubas¹, J Catesby Ware², Mariana Szklo-Coxe³

Affiliations

¹ School of Community and Environmental Health, College of Health Sciences, Old Dominion University, Norfolk, VA, USA.
² Division of Sleep Medicine, Department of Internal Medicine, Eastern Virginia Medical School, Norfolk, VA, USA.
³ School of Community and Environmental Health, College of Health Sciences, Old Dominion University, Norfolk, VA, USA; Division of Sleep Medicine, Department of Internal Medicine, Eastern Virginia Medical School, Norfolk, VA, USA. Electronic address: mszklo@odu.edu.

PMID: 31669818
DOI: 10.1016/j.sleep.2019.05.014

Abstract

Objective/background: A historic cohort single-center study of kidney transplant recipients with graft loss examined the associations between sleep apnea and two transplant outcomes, death with a functioning graft (DWFG), and graft survival time.

Patient/methods: Adult patients who received transplants and experienced graft failure or DWFG from January 1, 1997 to January 1, 2017 constituted the cohort (n = 322). Data for the study were obtained by merging two secondary data sources: the Organ Procurement and Transplantation Network (OPTN) database and the transplant center's medical records. A Cox regression modeled the association of diagnosed sleep apnea, stratified by year-of transplant surgery, with graft survival time. Using backward elimination, this model was adjusted for recipient age, race/ethnicity, gender, functional status, donor age, and antigen mismatch.

Results: No statistically significant differences were found for proportions of DWFG in those with, versus without, sleep apnea, informing our censoring approach. When examining graft survival time, the Cox regression model was stratified given a sleep apnea and year-of-transplant interaction (p < 0.01, adjusted model). For patients transplanted between 1997 and 2008, sleep apnea was statistically significantly associated with a decreased risk of graft failure or cardiovascular-related DWFG [adjusted Hazard Ratio (aHR) = 0.63, 95%CI, 0.42-0.94]. For patients transplanted between 2009 and 2017, sleep apnea statistically significantly increased the risk of graft failure or cardiovascular-related DWFG (aHR = 2.61, 95%CI, 1.13-6.00).

Conclusions: In a cohort of transplant recipients with graft loss, sleep apnea increased the risk of graft loss nearly three-fold among patients transplanted between 2009 and 2017. Similar DWFG proportions by sleep apnea presence indicate this risk is likely driven by renal failure, not mortality. Further research on whether treatment of sleep apnea can improve graft survival is warranted.

Keywords: Graft survival; Mortality; Sleep apnea; Survival analysis; Transplant.

Publication types

Research Support, U.S. Gov't, P.H.S.

MeSH terms

Cohort Studies
Databases, Factual
Female
Graft Survival*
Humans
Kidney Transplantation* / mortality
Kidney Transplantation* / statistics & numerical data
Longitudinal Studies
Male
Middle Aged
Sleep Apnea Syndromes* / diagnosis
Sleep Apnea Syndromes* / etiology
Transplant Recipients