Room temperature/Corcoran/Dow Corning™-Silicone plastination process

Anat Histol Embryol. 2019 Nov;48(6):539-546. doi: 10.1111/ahe.12505. Epub 2019 Oct 31.

Abstract

For 20 years, the cold temperature/S10/von Hagens' plastination technique was used to preserve biological specimens without challenge. It became the "gold standard" for preservation of beautiful, dry biological specimens. Near the end of the 21st century, a group from the University of Michigan and environs and Dow Corning™, USA, combined silicone ingredients, similar to the von Hagens' plastination products, however in a different sequence. The new polymer (Cor-tech) was combined with the cross-linker to design the "impregnation mix" which would invade the cellular structure of the specimen and yet was stable at room temperature. Later, curing would be by application of the catalyst onto the impregnated specimen. This unique sequencing of products would become the "Room temperature/Dow Corning™/Corcoran-Silicone plastination technique." The results of this room temperature technique provided similar plastinates, beautiful and practical for demonstration, containing no toxic chemical residues and forever preserved. As the name implies, impregnation of this silicone mix could be done at room temperature, without having to be kept cold. Both processes (cold and room temperature) required the same four basic steps for plastination. As well, both processes used similar basic polymers and additives to produce plastinates. However, they were combined in a different sequence. Cold temperature combines polymer and catalyst/chain extender, which is not stable and therefore must be kept colder than -15°C, while room temperature combines polymer with cross-linker which is stable, and likely forever.

Keywords: degreasing; dehydration; freeze substitution; impregnation; low molecular weight silicone; plastinate; room temperature plastination.

MeSH terms

  • Animals
  • Humans
  • Plastination / methods*
  • Polymers
  • Silicones
  • Temperature

Substances

  • Polymers
  • Silicones