Soluble Triggering Receptor Expressed on Myeloid Cells-1: Diagnosis or Prognosis?

Crit Care Clin. 2020 Jan;36(1):41-54. doi: 10.1016/j.ccc.2019.08.004. Epub 2019 Oct 18.

Abstract

The diagnosis of sepsis, and especially its differentiation from sterile inflammation, may be challenging. The triggering receptor expressed on myeloid cells-1 is an amplifier of the innate immune response. Its soluble form is detectable in various biological fluids and can be used as a surrogate marker of triggering receptor expressed on myeloid cells-1 activation. In this article, we review the abundant literature evaluating the usefulness of soluble triggering receptor expressed on myeloid cells-1 for the diagnosis and the prognosis evaluation of sepsis or localized infections.

Keywords: Biomarker; Diagnosis; Prognosis; Sepsis; sTREM-1.

Publication types

  • Review

MeSH terms

  • Biomarkers / blood*
  • Humans
  • Immunity, Innate
  • Myeloid Cells / immunology
  • Myeloid Cells / pathology*
  • Prognosis
  • Sepsis / blood*
  • Sepsis / diagnosis
  • Sepsis / immunology*
  • Sepsis / pathology*
  • Triggering Receptor Expressed on Myeloid Cells-1 / blood*
  • Triggering Receptor Expressed on Myeloid Cells-1 / immunology*

Substances

  • Biomarkers
  • Triggering Receptor Expressed on Myeloid Cells-1