Chaperone biomarkers of lifespan and penetrance track the dosages of many other proteins

Nat Commun. 2019 Dec 16;10(1):5725. doi: 10.1038/s41467-019-13664-7.

Abstract

Many traits vary among isogenic individuals in homogeneous environments. In microbes, plants and animals, variation in the protein chaperone system affects many such traits. In the animal model C. elegans, the expression level of hsp-16.2 chaperone biomarkers correlates with or predicts the penetrance of mutations and lifespan after heat shock. But the physiological mechanisms causing cells to express different amounts of the biomarker were unknown. Here, we used an in vivo microscopy approach to dissect different contributions to cell-to-cell variation in hsp-16.2 expression in the intestines of young adult animals, which generate the most lifespan predicting signal. While we detected both cell autonomous intrinsic noise and signaling noise, we found both contributions were relatively unimportant. The major contributor to cell-to-cell variation in biomarker expression was general differences in protein dosage. The hsp-16.2 biomarker reveals states of high or low effective dosage for many genes.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Animals, Genetically Modified
  • Biomarkers / metabolism
  • Caenorhabditis elegans / physiology
  • Caenorhabditis elegans Proteins / genetics*
  • Caenorhabditis elegans Proteins / metabolism
  • Gene Dosage*
  • Genes, Reporter / genetics
  • Heat-Shock Proteins / genetics*
  • Heat-Shock Proteins / metabolism
  • Intravital Microscopy / methods
  • Longevity / genetics*
  • Luminescent Proteins / genetics
  • Luminescent Proteins / metabolism
  • Microscopy, Fluorescence / methods
  • Models, Animal
  • Molecular Imaging
  • Penetrance*
  • Signal Transduction / genetics

Substances

  • Biomarkers
  • Caenorhabditis elegans Proteins
  • Heat-Shock Proteins
  • Luminescent Proteins
  • hsp-16.2 protein, C elegans