Boron dipyrromethene (BODIPY) is a class of important emerging fluorescent dyes. Due to their unique chemical and optical properties, near infrared (NIR)-emitting BODIPY dyes containing nanoparticles have recently been developed for a wide array of cutting-edge cancer optotheranostic applications. These nanoparticles not only have robust photostability and tunable photophysical properties, but they can also be flexibly tailored to a multitude of functional uses. Based on these outstanding characteristics, such nanoparticles have shown great promise in diagnosis as biological sensors, as well as in their utilization in advanced imaging and photomedicine for cancer treatment. In particular, here, this study first discusses their use as photoswitchable fluorescence probes toward in vitro single-molecule imaging. Second, this study takes a look at their opportunities for photoacoustic imaging utilization. Third, approaches are discussed to construct new NIR-absorbing BODIPY nanoparticles for photodynamic therapy (PDT). Fourth, this study delves into the new approach to use such nanoparticles as an emerging version of triplet-triplet annihilation upconversion (TTA-UC) and their biological uses, such as their photoactivation prodrug therapy (PAPT) for cancer. Finally, new biological sensors based on NIR BODIPY nanoparticles are introduced.
Keywords: BODIPY; cancer; near infrared; optotheranostics.