Clinical Characteristics of Invasive Fungal Infections in Pediatric Oncology Patients With Solid Tumors

J Pediatr Hematol Oncol. 2021 Apr 1;43(3):e408-e413. doi: 10.1097/MPH.0000000000001761.

Abstract

Invasive fungal infections (IFIs) are an important cause of morbidity and mortality in children with cancer. Studies on the clinical characteristics of IFI in children with solid tumors are limited. This Dutch retrospective cohort study reviewed the medical records of 61 children with solid tumors to analyze the clinical characteristics during their full treatment period. Seven IFI episodes were reported in 6/61 patients (10%), all diagnosed with intermediate-risk or high-risk Wilms tumor or neuroblastoma. Larger studies are necessary to reveal the determinants of IFI in this group of patients and the value of fungal prophylaxis.

Publication types

  • Case Reports

MeSH terms

  • Antifungal Agents / therapeutic use
  • Antineoplastic Agents / therapeutic use
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Invasive Fungal Infections / complications*
  • Invasive Fungal Infections / drug therapy
  • Invasive Fungal Infections / pathology
  • Male
  • Neoplasms / complications*
  • Neoplasms / drug therapy
  • Neoplasms / pathology
  • Neuroblastoma / complications
  • Neuroblastoma / drug therapy
  • Neuroblastoma / pathology
  • Retrospective Studies
  • Wilms Tumor / complications
  • Wilms Tumor / drug therapy
  • Wilms Tumor / pathology

Substances

  • Antifungal Agents
  • Antineoplastic Agents