Association analysis of 15 GWAS-linked loci with Parkinson's disease in Chinese Han population

Xinchao Hu; Chengyuan Mao; Zhengwei Hu; Zhongxian Zhang; Shuo Zhang; Zhihua Yang; Yu Fan; Liyuan Fan; Huimin Zheng; Jing Yang; Yutao Liu; Yanpeng Yuan; Yaohe Wang; Changhe Shi; Yuming Xu

doi:10.1016/j.neulet.2020.134867

Association analysis of 15 GWAS-linked loci with Parkinson's disease in Chinese Han population

Neurosci Lett. 2020 Apr 23:725:134867. doi: 10.1016/j.neulet.2020.134867. Epub 2020 Mar 9.

Authors

Xinchao Hu¹, Chengyuan Mao², Zhengwei Hu¹, Zhongxian Zhang³, Shuo Zhang¹, Zhihua Yang¹, Yu Fan¹, Liyuan Fan¹, Huimin Zheng¹, Jing Yang², Yutao Liu², Yanpeng Yuan², Yaohe Wang³, Changhe Shi⁴, Yuming Xu⁵

Affiliations

¹ Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, 450000, Henan, China; The Academy of Medical Sciences of Zhengzhou University, Zhengzhou University, Zhengzhou, 450000, Henan, China.
² Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, 450000, Henan, China.
³ Sino-British Research Centre for Molecular Oncology, National Centre for International Research in Cell and Gene Therapy, School of Basic Medical Sciences, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, 450000, Henan, China; The Academy of Medical Sciences of Zhengzhou University, Zhengzhou University, Zhengzhou, 450000, Henan, China.
⁴ Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, 450000, Henan, China. Electronic address: shichanghe@gmail.com.
⁵ Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, 450000, Henan, China. Electronic address: xuyuming@zzu.edu.cn.

PMID: 32165260
DOI: 10.1016/j.neulet.2020.134867

Abstract

Genetic factors play an important role in Parkinson's disease (PD) and vary from different races. A previous genome-wide association study (GWAS) identified 17 novel risk loci that were associated with PD in Caucasians. Several subsequent studies investigated the association between these loci and PD in Chinese populations. However, the results on the role of these variants for PD have been conflicting. To explore the relationship of 15 controversial loci with PD in the Chinese Han population, we performed a case-control study including 492 PD patients and 524 healthy controls. iMLDR technology was used to type 15 GWAS-linked loci of 1016 blood samples from all subjects. We found that rs34043159 (IL1R2) (dominant model after adjusted: p = 0.011, OR 95 % CI 0.577 (0.378-0.880)) and rs4073221 (SATB1) (allele model: p = 0.001, OR 95 % CI 0.542 (0.371-0.792); dominant model after adjusted: p = 0.049, OR 95 % CI 0.587 (0.345-0.998)) were associated with PD. After age onset and gender subgroup analysis, rs34043159 (IL1R2) (χ² = 7.971, p = 0.019) and rs4073221 (SATB1) (χ² = 12.673, p = 0.001) were associated with late-onset PD. rs34043159 (IL1R2) was associated with PD in females (χ² = 7.227, p = 0.027) rather than males (χ² = 1.100, p = 0.577). rs4073221 (SATB1) was associated with PD in both males (χ² = 10.270, p = 0.005) and females (χ² = 7.050, p = 0.022). Further studies are needed to explore the role of IL1R2 and SATB1 in the pathogenesis of PD.

Keywords: Association; Parkinson’s disease; Single nucleotide polymorphism; The Chinese Han population.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Asian People / ethnology
Asian People / genetics*
Female
Genetic Loci / genetics*
Genome-Wide Association Study / methods*
Humans
Male
Middle Aged
Parkinson Disease / diagnosis
Parkinson Disease / ethnology
Parkinson Disease / genetics*
Polymorphism, Single Nucleotide / genetics*
Population Surveillance / methods*