A STIMulating journey into optogenetic engineering

Guolin Ma; Yubin Zhou

doi:10.1016/j.ceca.2020.102197

A STIMulating journey into optogenetic engineering

Cell Calcium. 2020 May 4:88:102197. doi: 10.1016/j.ceca.2020.102197. Online ahead of print.

Authors

Guolin Ma¹, Yubin Zhou²

Affiliations

¹ Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M University, Houston, TX 77030, USA. Electronic address: gma@tamu.edu.
² Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M University, Houston, TX 77030, USA. Electronic address: yubinzhou@tamu.edu.

Abstract

Genetically-encoded calcium actuators (GECAs) stemmed from STIM1 have enabled optical activation of endogenous ORAI1 channels in both excitable and non-excitable tissues. These GECAs offer new non-invasive means to probe the structure-function relations of calcium channels and wirelessly control the behavior of awake mice.

Keywords: CRAC channel; Calcium signaling; Optogenetics; STIM1.

Abstract

Grants and funding