Abstract
The study of postsynaptic excitation to inhibition (E/I ratio) imbalances in human brain diseases, is a highly relevant functional measurement poorly investigated due to postmortem degradation of synaptic receptors. We show that near-simultaneous recording of microtransplanted synaptic receptors after simulated morgue conditions allows the determination of the postsynaptic E/I ratio for at least 120 h after death, expanding the availability and use of human diseased tissue stored in brain banks.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Animals
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Brain / physiology*
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Brain Diseases / pathology
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Excitatory Postsynaptic Potentials / drug effects
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Excitatory Postsynaptic Potentials / physiology*
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Female
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Humans
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Inhibitory Postsynaptic Potentials / drug effects
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Inhibitory Postsynaptic Potentials / physiology*
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Kainic Acid / pharmacology
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Male
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Oocytes / cytology
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Oocytes / metabolism
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Rats
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Rats, Wistar
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Receptors, Neurotransmitter / metabolism
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Synaptosomes / drug effects
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Synaptosomes / physiology
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Temperature
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Time Factors
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gamma-Aminobutyric Acid / pharmacology
Substances
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Receptors, Neurotransmitter
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gamma-Aminobutyric Acid
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Kainic Acid