Unrestrained ESCRT-III drives micronuclear catastrophe and chromosome fragmentation

Nat Cell Biol. 2020 Jul;22(7):856-867. doi: 10.1038/s41556-020-0537-5. Epub 2020 Jun 29.

Abstract

The ESCRT-III membrane fission machinery maintains the integrity of the nuclear envelope. Although primary nuclei resealing takes minutes, micronuclear envelope ruptures seem to be irreversible. Instead, micronuclear ruptures result in catastrophic membrane collapse and are associated with chromosome fragmentation and chromothripsis, complex chromosome rearrangements thought to be a major driving force in cancer development. Here we use a combination of live microscopy and electron tomography, as well as computer simulations, to uncover the mechanism underlying micronuclear collapse. We show that, due to their small size, micronuclei inherently lack the capacity of primary nuclei to restrict the accumulation of CHMP7-LEMD2, a compartmentalization sensor that detects loss of nuclear integrity. This causes unrestrained ESCRT-III accumulation, which drives extensive membrane deformation, DNA damage and chromosome fragmentation. Thus, the nuclear-integrity surveillance machinery is a double-edged sword, as its sensitivity ensures rapid repair at primary nuclei while causing unrestrained activity at ruptured micronuclei, with catastrophic consequences for genome stability.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Nucleus / genetics
  • Cell Nucleus / metabolism
  • Cell Nucleus / pathology*
  • Chromatin / genetics
  • Chromatin / metabolism*
  • Chromosome Aberrations*
  • DNA Damage*
  • Endosomal Sorting Complexes Required for Transport / genetics
  • Endosomal Sorting Complexes Required for Transport / metabolism*
  • Genomic Instability*
  • HeLa Cells
  • Humans
  • Membrane Proteins / metabolism*
  • Nuclear Proteins / metabolism*

Substances

  • Chromatin
  • Endosomal Sorting Complexes Required for Transport
  • LEMD2 protein, human
  • Membrane Proteins
  • Nuclear Proteins