Targeting inflammation and cytokine storm in COVID-19

Pharmacol Res. 2020 Sep:159:105051. doi: 10.1016/j.phrs.2020.105051. Epub 2020 Jun 27.

Authors

Qianwen Huang¹, Xiumei Wu¹, Xueying Zheng², Sihui Luo², Suowen Xu³, Jianping Weng⁴

Affiliations

¹ Department of Endocrinology and Metabolism, Guangdong Provincial Key Laboratory of Diabetology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
² Department of Endocrinology, First Affiliated Hospital, Division of Life Sciences and Medicine, University of Science and Technology of China (USTC), Hefei, China.
³ Department of Endocrinology, First Affiliated Hospital, Division of Life Sciences and Medicine, University of Science and Technology of China (USTC), Hefei, China. Electronic address: sxu1984@ustc.edu.cn.
⁴ Department of Endocrinology, First Affiliated Hospital, Division of Life Sciences and Medicine, University of Science and Technology of China (USTC), Hefei, China. Electronic address: wengjp@ustc.edu.cn.

No abstract available

MeSH terms

Anti-Inflammatory Agents / therapeutic use
Betacoronavirus*
COVID-19
COVID-19 Drug Treatment
Cell Cycle Proteins / antagonists & inhibitors
Coronavirus Infections / drug therapy*
Coronavirus Infections / immunology
Coronavirus Infections / virology
Cytokines / metabolism*
Host Microbial Interactions / drug effects
Host Microbial Interactions / immunology
Humans
Immunologic Factors / therapeutic use
Inflammasomes / drug effects
Inflammasomes / immunology
Inflammation / drug therapy*
Inflammation / immunology
Inflammation / virology
Interleukin-6 / antagonists & inhibitors
Models, Immunological
NLR Family, Pyrin Domain-Containing 3 Protein / antagonists & inhibitors
Pandemics
Pneumonia, Viral / drug therapy*
Pneumonia, Viral / immunology
Pneumonia, Viral / virology
SARS-CoV-2
Transcription Factors / antagonists & inhibitors

Substances

Anti-Inflammatory Agents
BRD4 protein, human
Cell Cycle Proteins
Cytokines
IL6 protein, human
Immunologic Factors
Inflammasomes
Interleukin-6
NLR Family, Pyrin Domain-Containing 3 Protein
NLRP3 protein, human
Transcription Factors