Sub-group, Sub-type, and Cell-type Heterogeneity of Ependymoma

Stephen C Mack; Kelsey C Bertrand

doi:10.1016/j.ccell.2020.06.010

Sub-group, Sub-type, and Cell-type Heterogeneity of Ependymoma

Cancer Cell. 2020 Jul 13;38(1):15-17. doi: 10.1016/j.ccell.2020.06.010.

Authors

Stephen C Mack¹, Kelsey C Bertrand²

Affiliations

¹ Baylor College of Medicine, Texas Children's Cancer and Hematology Centers, Dan L. Duncan Cancer Center, Houston, TX 77030, USA. Electronic address: scmack@bcm.edu.
² Baylor College of Medicine, Texas Children's Cancer and Hematology Centers, Dan L. Duncan Cancer Center, Houston, TX 77030, USA.

PMID: 32663463
DOI: 10.1016/j.ccell.2020.06.010

Abstract

Ependymomas are aggressive central nervous system tumors that resist chemotherapy. In this issue of Cancer Cell, Gojo et al. dissect the single cell transcriptional landscapes of ependymoma to define cellular programs that mediate therapeutic resistance, tumor aggressiveness, and potential targets for therapy.

Publication types

Comment

MeSH terms

Central Nervous System Neoplasms*
Child
Ependymoma* / drug therapy
Ependymoma* / genetics
Humans
RNA-Seq