Abstract
Product analysis from the iron Fenton oxidation of 2'-deoxyguanosine found reactions in bicarbonate buffer yield 8-oxo-2'-deoxyguanosine and spiroiminodihyantoin consistent with CO3˙-. Reactions in phosphate buffer furnished high yields of sugar oxidation products consistent with HO˙. These observations change the view of DNA oxidation products from the iron-Fenton reaction.
MeSH terms
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Anions / chemistry
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Bicarbonates / chemistry*
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Carbonates / chemistry*
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Deoxyadenosines / chemistry
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Deoxyguanosine / chemistry*
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Free Radicals / chemistry
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Free Radicals / metabolism*
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Hydrogen Peroxide / chemistry*
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Hydroxyl Radical / chemistry
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Iron / chemistry*
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Oxidation-Reduction
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Reactive Oxygen Species / metabolism*
Substances
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Anions
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Bicarbonates
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Carbonates
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Deoxyadenosines
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Fenton's reagent
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Free Radicals
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Reactive Oxygen Species
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Hydroxyl Radical
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2'-deoxy-7,8-dihydro-8-oxoadenosine
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Hydrogen Peroxide
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Iron
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Deoxyguanosine