External versus internal cardioversion for atrial fibrillation: a meta-analysis of randomized controlled trials

J Interv Card Electrophysiol. 2021 Sep;61(3):445-451. doi: 10.1007/s10840-020-00836-5. Epub 2020 Jul 31.

Abstract

Background: Patients with atrial fibrillation (AF) often require rhythm control strategy for amelioration of symptoms. It is unclear if there is any difference between external cardioversion (ECV) and internal cardioversion (ICV) for successful conversion of AF to normal sinus rhythm.

Methods: We performed a meta-analysis of published randomized controlled trials (RCTs) evaluating success of cardioversion using ECV versus ICV.

Results: In the pooled analysis of 5 RCTS, there was no difference in success of cardioversion using ECV versus ICV (OR 1.69, 95% CI 0.24-11.83, p = 0.6). In the subgroup analysis, there was no difference between ECV and direct electrode ICV (OR 0.41, 95% CI 0.09-1.83, p = 0.24). However, ECV was significantly better compared with ICV using ICD (OR 11.97, 95% CI 1.87-76.73, p = 0.009).

Conclusions: There was no difference between ECV versus ICV in effectiveness for termination of AF. Larger well-designed randomized controlled trials are needed to confirm our findings.

Keywords: Atrial fibrillation; Cardioversion; Implantable cardioverter-defibrillator; Randomized controlled trial; Rhythm control.

Publication types

  • Meta-Analysis

MeSH terms

  • Atrial Fibrillation* / diagnostic imaging
  • Atrial Fibrillation* / therapy
  • Electric Countershock*
  • Electrodes
  • Humans
  • Randomized Controlled Trials as Topic
  • Treatment Outcome