TERT promotor variant associated with poor clinical outcome in a patient with novel RBM15-MKL1 fusion-positive pediatric acute megakaryoblastic leukemia

Pediatr Blood Cancer. 2021 Jan;68(1):e28542. doi: 10.1002/pbc.28542. Epub 2020 Aug 2.
No abstract available

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Fatal Outcome
  • Female
  • Humans
  • Infant
  • Leukemia, Megakaryoblastic, Acute / drug therapy
  • Leukemia, Megakaryoblastic, Acute / genetics
  • Leukemia, Megakaryoblastic, Acute / pathology*
  • Oncogene Proteins, Fusion / genetics*
  • Polymorphism, Single Nucleotide*
  • Promoter Regions, Genetic*
  • RNA-Binding Proteins / genetics*
  • Telomerase / genetics*
  • Trans-Activators / genetics*

Substances

  • MRTFA protein, human
  • Oncogene Proteins, Fusion
  • RBM15 protein, human
  • RNA-Binding Proteins
  • Trans-Activators
  • TERT protein, human
  • Telomerase