COVAN is the new HIVAN: the re-emergence of collapsing glomerulopathy with COVID-19

Nat Rev Nephrol. 2020 Oct;16(10):565-567. doi: 10.1038/s41581-020-0332-3.

Abstract

Reports of collapsing glomerulopathy in patients of African ancestry and high-risk APOL1 genotype infected with SARS-CoV-2 have emerged during the COVID-19 pandemic. This new entity, which we term COVID-19-associated nephropathy (COVAN), may particularly impact individuals in some regions of the world. Awareness of this potentially ominous complication of COVID-19 must be raised.

Publication types

  • Review

MeSH terms

  • AIDS-Associated Nephropathy / epidemiology
  • AIDS-Associated Nephropathy / etiology*
  • AIDS-Associated Nephropathy / genetics
  • Apolipoprotein L1 / genetics*
  • Apolipoprotein L1 / metabolism
  • Betacoronavirus*
  • COVID-19
  • Coronavirus Infections / complications*
  • Coronavirus Infections / epidemiology
  • DNA / genetics*
  • Global Health
  • Humans
  • Incidence
  • Pandemics
  • Pneumonia, Viral / complications*
  • Pneumonia, Viral / epidemiology
  • Polymorphism, Single Nucleotide*
  • SARS-CoV-2

Substances

  • APOL1 protein, human
  • Apolipoprotein L1
  • DNA