A COVID-19 mRNA vaccine encoding SARS-CoV-2 virus-like particles induces a strong antiviral-like immune response in mice

Jing Lu; Guoliang Lu; Shudan Tan; Jia Xia; Hualong Xiong; Xiaofei Yu; Qingqing Qi; Xiang Yu; Li Li; Hang Yu; Ningshao Xia; Tianying Zhang; Yingjie Xu; Jinzhong Lin

doi:10.1038/s41422-020-00392-7

A COVID-19 mRNA vaccine encoding SARS-CoV-2 virus-like particles induces a strong antiviral-like immune response in mice

Cell Res. 2020 Oct;30(10):936-939. doi: 10.1038/s41422-020-00392-7. Epub 2020 Aug 17.

Authors

Jing Lu^#¹, Guoliang Lu^#¹, Shudan Tan^#¹, Jia Xia^#², Hualong Xiong^#³, Xiaofei Yu^#⁴, Qingqing Qi⁴, Xiang Yu⁵, Li Li¹, Hang Yu⁶, Ningshao Xia³, Tianying Zhang⁷, Yingjie Xu⁸, Jinzhong Lin⁹

Affiliations

¹ State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Fudan University, Shanghai, 200438, China.
² Department of Urology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China.
³ State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences and School of Public Health, Xiamen University, Xiamen, Fujian, 361102, China.
⁴ State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, 200438, China.
⁵ Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Department of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
⁶ Shanghai RNACure Biopharma Co., Ltd, Shanghai, 200438, China.
⁷ State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences and School of Public Health, Xiamen University, Xiamen, Fujian, 361102, China. tyzhang1003@163.com.
⁸ Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Department of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. xuyingjie@shsmu.edu.cn.
⁹ State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Fudan University, Shanghai, 200438, China. linjinzhong@fudan.edu.cn.

^# Contributed equally.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Betacoronavirus / genetics*
Betacoronavirus / immunology
COVID-19
COVID-19 Vaccines
Coronavirus Envelope Proteins
Coronavirus Infections / genetics
Coronavirus Infections / immunology
Coronavirus Infections / prevention & control*
HEK293 Cells
Humans
Immunity, Cellular
Immunity, Humoral
Immunization
Mice
Pandemics / prevention & control*
Pneumonia, Viral / immunology
Pneumonia, Viral / prevention & control*
RNA, Messenger / genetics
RNA, Messenger / pharmacology
RNA, Messenger / therapeutic use*
SARS-CoV-2
Spike Glycoprotein, Coronavirus / genetics
Spike Glycoprotein, Coronavirus / immunology
Vaccines, Virus-Like Particle / genetics
Vaccines, Virus-Like Particle / pharmacology
Vaccines, Virus-Like Particle / therapeutic use*
Viral Envelope Proteins / genetics
Viral Envelope Proteins / immunology
Viral Matrix Proteins / genetics
Viral Matrix Proteins / immunology
Viral Vaccines / genetics
Viral Vaccines / pharmacology
Viral Vaccines / therapeutic use*

Substances

COVID-19 Vaccines
Coronavirus Envelope Proteins
RNA, Messenger
Spike Glycoprotein, Coronavirus
Vaccines, Virus-Like Particle
Viral Envelope Proteins
Viral Matrix Proteins
Viral Vaccines
envelope protein, SARS-CoV-2
membrane protein, SARS-CoV-2
spike protein, SARS-CoV-2

Grants and funding

2017SHZDZX01/Science and Technology Commission of Shanghai Municipality (Shanghai Municipal Science and Technology Commission)/International