Symptomatic xanthogranuloma of the lateral ventricle in a pregnant patient treated with delayed resection: A case report and systematic review

Clin Neurol Neurosurg. 2020 Nov:198:106143. doi: 10.1016/j.clineuro.2020.106143. Epub 2020 Aug 11.

Abstract

Intracranial xanthogranulomas (XG) are a rare benign histiocytic neoplasm and most often within the choroid. The majority are asymptomatic and are found incidentally on imaging or post-mortem examination or autopsy. We present a case of symptomatic XG in a pregnant patient who underwent a delayed transcortical, transventricular approach for lateral ventricle XG resection following the completion of her pregnancy. Four years post-operatively, the patient is neurologically intact and without recurrence. Our review of the literature showed differences among XG depending on location. The clinical and radiological features of XG are often indistinguishable from tumors arising from the choroid plexus and should be considered as a rare etiology in the differential of newly diagnosed intraventricular lesions.

Keywords: Delayed surgical resection; Intracranial mass; Intraventricular mass; Pregnancy; Xanthogranuloma.

Publication types

  • Case Reports
  • Systematic Review

MeSH terms

  • Adult
  • Brain Diseases / diagnostic imaging
  • Brain Diseases / pathology*
  • Female
  • Granuloma / diagnostic imaging
  • Granuloma / pathology*
  • Granuloma / surgery*
  • Humans
  • Lateral Ventricles / diagnostic imaging
  • Lateral Ventricles / pathology*
  • Magnetic Resonance Imaging
  • Pregnancy
  • Pregnancy Complications / pathology*
  • Xanthomatosis / diagnostic imaging
  • Xanthomatosis / pathology*
  • Xanthomatosis / surgery*