Infection prophylaxis patterns following pediatric autologous hematopoietic stem cell transplantation: A survey of Pediatric Transplant and Cell Therapy Consortium centers

Corey P Falcon; Larisa Broglie; Rachel Phelan; Sung W Choi; Jeffery J Auletta; Joseph H Chewning

doi:10.1111/petr.13821

Infection prophylaxis patterns following pediatric autologous hematopoietic stem cell transplantation: A survey of Pediatric Transplant and Cell Therapy Consortium centers

Pediatr Transplant. 2020 Dec;24(8):e13821. doi: 10.1111/petr.13821. Epub 2020 Aug 25.

Authors

Corey P Falcon^{1

2

3}, Larisa Broglie⁴, Rachel Phelan⁵, Sung W Choi⁶, Jeffery J Auletta⁷, Joseph H Chewning¹

Affiliations

¹ Pediatric Blood and Marrow Transplant Program, University of Alabama at Birmingham, Birmingham, Alabama, USA.
² Division of Hematology Oncology, Tulane Department of Pediatrics, New Orleans, LA, USA.
³ Division of Pediatric Hematology/Oncology, Ochsner Hospital for Children, New Orleans, LA, USA.
⁴ Division of Pediatric Stem Cell Transplantation, Columbia University Medical Center, New York, New York, USA.
⁵ Division of Pediatric Hematology/Oncology, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
⁶ Pediatric Blood and Marrow Transplant Program, University of Michigan, Ann Arbor, Michigan, USA.
⁷ Hematology/Oncology/BMT and Infectious Diseases, Nationwide Children's Hospital, Columbus, Ohio, USA.

PMID: 32844543
DOI: 10.1111/petr.13821

Abstract

No standardized guidelines exist for infectious prophylaxis following pediatric auto-HSCT. We hypothesized significant variation in clinical practice. Thirty-three Pediatric Transplant and Cell Therapy Consortium centers completed a survey to assess institutional management. The majority utilize viral (91%) and fungal prophylaxis (94%), but duration varies. Bacterial prophylaxis during neutropenia is instituted by 42%. Our study demonstrates marked practice variability in infectious prophylaxis across centers. Additional research is needed to address patterns of infectious complications and to develop meaningful clinical practice guidelines for pediatric auto-HSCT.

Keywords: PTCTC survey; pediatric autologous HSCT; post auto-HSCT infection prophylaxis protocol.

Publication types

Multicenter Study

MeSH terms

Child
Drug Resistance
Hematopoietic Stem Cell Transplantation*
Humans
Infections / drug therapy*
Infections / microbiology*
Postoperative Complications / microbiology*
Postoperative Complications / prevention & control*
Practice Patterns, Physicians' / statistics & numerical data*
Surveys and Questionnaires