The key point for microvascular reconstruction is to preserve patency of flap vessels. Despite great improvement in reconstruction success rates in the last 30 years, ischemic complications are still an undesirable event. The authors assessed recent as well as older literature and compared progression in perioperative pharmacology interventions in antithrombotic prevention.
Keywords: Thrombosis; antithrombotic; flap ischemia; free flap; microvascular anastomosis; vasospasm.