Epigenetic loss of m1A RNA demethylase ALKBH3 in Hodgkin lymphoma targets collagen, conferring poor clinical outcome

Blood. 2021 Feb 18;137(7):994-999. doi: 10.1182/blood.2020005823.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase / deficiency*
  • AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase / genetics
  • AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase / metabolism
  • Base Sequence
  • Cell Line, Tumor
  • Collagen Type I / biosynthesis*
  • Collagen Type I / genetics
  • Collagen Type I, alpha 1 Chain
  • CpG Islands / genetics
  • DNA Methylation* / drug effects
  • DNA, Neoplasm / genetics
  • DNA, Neoplasm / metabolism
  • Datasets as Topic
  • Decitabine / pharmacology
  • Hodgkin Disease / enzymology*
  • Hodgkin Disease / genetics
  • Hodgkin Disease / metabolism
  • Humans
  • Leukocytes, Mononuclear / metabolism
  • Lymphocytes / metabolism
  • Methylation / drug effects
  • Neoplasm Proteins / genetics
  • Neoplasm Proteins / metabolism*
  • Promoter Regions, Genetic / genetics
  • RNA Interference*
  • RNA Processing, Post-Transcriptional* / drug effects
  • RNA, Neoplasm / metabolism*
  • Sequence Alignment
  • tRNA Methyltransferases / metabolism

Substances

  • COL1A2 protein, human
  • Collagen Type I
  • Collagen Type I, alpha 1 Chain
  • DNA, Neoplasm
  • Neoplasm Proteins
  • RNA, Neoplasm
  • Decitabine
  • ALKBH3 protein, human
  • AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase
  • tRNA Methyltransferases
  • tRNA (adenine(58)-N(1))-methyltransferase