Nucleosomes Meet Their Remodeler Match

Jonathan Markert; Karolin Luger

doi:10.1016/j.tibs.2020.08.010

Nucleosomes Meet Their Remodeler Match

Trends Biochem Sci. 2021 Jan;46(1):41-50. doi: 10.1016/j.tibs.2020.08.010. Epub 2020 Sep 8.

Authors

Jonathan Markert¹, Karolin Luger²

Affiliations

¹ Department of Biochemistry, University of Colorado at Boulder, Boulder, CO 80309, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA.
² Department of Biochemistry, University of Colorado at Boulder, Boulder, CO 80309, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA. Electronic address: karolin.luger@colorado.edu.

PMID: 32917506
DOI: 10.1016/j.tibs.2020.08.010

Abstract

Over 85% of all genomic DNA in eukaryotes is organized in arrays of nucleosomes, the basic organizational principle of chromatin. The tight interaction of DNA with histones represents a significant barrier for all DNA-dependent machineries. This is in part overcome by enzymes, termed ATP-dependent remodelers, that are recruited to nucleosomes at defined locations and modulate their structure. There are several different classes of remodelers, and all use specific nucleosome features to bind to and alter nucleosomes. This review highlights and summarizes areas of interactions with the nucleosome that allow remodeling to occur.

Keywords: ATP-dependent chromatin-remodeling factor; DNA accessibility; cryo-EM; nucleosome.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

DNA / metabolism*
DNA Repair
DNA Replication
Nucleosomes / metabolism*
RNA / metabolism*

Substances

Nucleosomes
RNA
DNA