Genomic instability and mitochondrial homeostasis in cancer: does chromatin have a say?

Yue Liu; Haojian Li; Susan E Zimmerman; Urbain Weyemi

doi:10.1080/23723556.2020.1771959

Genomic instability and mitochondrial homeostasis in cancer: does chromatin have a say?

Mol Cell Oncol. 2020 Jul 13;7(5):1771959. doi: 10.1080/23723556.2020.1771959. eCollection 2020.

Authors

Yue Liu^{1

2}, Haojian Li^{1

2}, Susan E Zimmerman^{1

2}, Urbain Weyemi^{1

2}

Affiliations

¹ Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA.
² Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX, USA.

Abstract

While genomic instability and mitochondrial homeostasis are integral for cancer progression, how these two hallmarks interact remains poorly understood. Here, we reflect on the dialogue between chromatin-based genomic instability and impairment of mitochondrial function and depict the importance of this interaction in cancer progression to metastasis.

Keywords: Genomic instability; cancer; chromatin; metabolism; mitochondrial homeostasis.

Abstract

Grants and funding