Wireless Programmable Recording and Stimulation of Deep Brain Activity in Freely Moving Humans

Uros Topalovic; Zahra M Aghajan; Diane Villaroman; Sonja Hiller; Leonardo Christov-Moore; Tyler J Wishard; Matthias Stangl; Nicholas R Hasulak; Cory S Inman; Tony A Fields; Vikram R Rao; Dawn Eliashiv; Itzhak Fried; Nanthia Suthana

doi:10.1016/j.neuron.2020.08.021

Wireless Programmable Recording and Stimulation of Deep Brain Activity in Freely Moving Humans

Neuron. 2020 Oct 28;108(2):322-334.e9. doi: 10.1016/j.neuron.2020.08.021. Epub 2020 Sep 17.

Authors

Affiliations

¹ Department of Electrical and Computer Engineering, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA 90024, USA.
² Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA 90024, USA.
³ Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
⁴ NeuroPace, Mountain View, CA 94043, USA.
⁵ Department of Neurology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
⁶ Department of Neurology and Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94143, USA.
⁷ Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA 90024, USA; Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Tel Aviv Sourasky Medical Center and Sackler Faculty School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.
⁸ Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA 90024, USA; Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Psychology, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: nsuthana@mednet.ucla.edu.

Abstract

Uncovering the neural mechanisms underlying human natural ambulatory behavior is a major challenge for neuroscience. Current commercially available implantable devices that allow for recording and stimulation of deep brain activity in humans can provide invaluable intrinsic brain signals but are not inherently designed for research and thus lack flexible control and integration with wearable sensors. We developed a mobile deep brain recording and stimulation (Mo-DBRS) platform that enables wireless and programmable intracranial electroencephalographic recording and electrical stimulation integrated and synchronized with virtual reality/augmented reality (VR/AR) and wearables capable of external measurements (e.g., motion capture, heart rate, skin conductance, respiration, eye tracking, and scalp EEG). When used in freely moving humans with implanted neural devices, this platform is adaptable to ecologically valid environments conducive to elucidating the neural mechanisms underlying naturalistic behaviors and to the development of viable therapies for neurologic and psychiatric disorders.

Keywords: augmented reality; eye tracking; human; intracranial EEG; intracranial electrical stimulation; mobile EEG; neuroimaging methods; virtual reality; wearables.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Augmented Reality
Brain / physiology*
Deep Brain Stimulation / instrumentation*
Electroencephalography / instrumentation*
Electroencephalography / methods
Humans
Psychomotor Performance*
Signal Processing, Computer-Assisted
Software
Telemetry / instrumentation*
Virtual Reality
Wearable Electronic Devices*

Abstract

Publication types

MeSH terms

Grants and funding