PARP-1 Flips the Epigenetic Switch on Obesity

Carla E Margulies; Andreas G Ladurner

doi:10.1016/j.molcel.2020.08.019

PARP-1 Flips the Epigenetic Switch on Obesity

Mol Cell. 2020 Sep 17;79(6):874-875. doi: 10.1016/j.molcel.2020.08.019.

Authors

Carla E Margulies¹, Andreas G Ladurner²

Affiliations

¹ Biomedical Center, Department of Molecular Biology, Ludwig-Maximilians-University Munich, Grosshaderner Strasse 9, 82152 Planegg, Germany.
² Biomedical Center, Department of Physiological Chemistry, Ludwig-Maximilians-University Munich, Grosshaderner Strasse 9, 82152 Planegg, Germany; Eisbach Bio GmbH, Am Klopferspitz 19, 82152 Planegg, Germany. Electronic address: andreas.ladurner@bmc.med.lmu.de.

PMID: 32946760
DOI: 10.1016/j.molcel.2020.08.019

Abstract

PARP enzymes are increasingly taking on important roles beyond DNA repair. Huang et al. (2020b) report how the NAD⁺-dependent ADP-ribosylation of histone H2B by PARP-1 in complex with a metabolic enzyme suppresses the phosphorylation of an adjacent residue, impacting adipogenesis.

Publication types

Comment

MeSH terms

ADP-Ribosylation
Adipogenesis
Epigenesis, Genetic
Histones*
Humans
Obesity
Phosphorylation
Poly(ADP-ribose) Polymerase Inhibitors*
Poly(ADP-ribose) Polymerases

Substances

Histones
Poly(ADP-ribose) Polymerase Inhibitors
Poly(ADP-ribose) Polymerases