CYP2C19 status and risk of major adverse cardiovascular events in peripheral artery disease: Insights from the EUCLID Trial

Am Heart J. 2020 Nov:229:118-120. doi: 10.1016/j.ahj.2020.07.017. Epub 2020 Aug 16.
No abstract available

Publication types

  • Letter
  • Multicenter Study
  • Randomized Controlled Trial

MeSH terms

  • Cardiovascular Diseases* / diagnosis
  • Cardiovascular Diseases* / etiology
  • Cardiovascular Diseases* / mortality
  • Cardiovascular Diseases* / surgery
  • Clopidogrel* / administration & dosage
  • Clopidogrel* / adverse effects
  • Clopidogrel* / pharmacokinetics
  • Cytochrome P-450 CYP2C19 / genetics*
  • Extremities / blood supply
  • Female
  • Hemorrhage* / chemically induced
  • Hemorrhage* / diagnosis
  • Humans
  • Ischemia* / etiology
  • Ischemia* / surgery
  • Loss of Function Mutation
  • Male
  • Middle Aged
  • Outcome and Process Assessment, Health Care
  • Peripheral Arterial Disease* / complications
  • Peripheral Arterial Disease* / drug therapy
  • Peripheral Arterial Disease* / genetics
  • Pharmacogenomic Testing / methods
  • Platelet Aggregation Inhibitors / administration & dosage
  • Platelet Aggregation Inhibitors / adverse effects
  • Platelet Aggregation Inhibitors / pharmacokinetics
  • Vascular Surgical Procedures* / methods
  • Vascular Surgical Procedures* / statistics & numerical data

Substances

  • Platelet Aggregation Inhibitors
  • Clopidogrel
  • CYP2C19 protein, human
  • Cytochrome P-450 CYP2C19

Associated data

  • ClinicalTrials.gov/NCT01732822