1 Department of Emergency, Anesthesia and Intensive Care, Azienda Ospedaliero Universitaria (AOU) Policlinico San Marco University Hospital, Catania, Italy, maxsorbello@gmail.com Department of Anaesthesia, Guy's and St Thomas' National Health System (NHS) Foundation Trust, London, United Kingdom Anesthesia and Intensive Care Dipartimento di Medicina Perioperatoria, Dolore, Terapia Intensiva e Rapid Response System, Ospedale di Chieti, Università "G. D'Annunzio", Chieti-Pescara, Italy.