Prevalence of Clostridioides difficile associated diarrhea in hospitalized patients in five Brazilian centers: A multicenter, prospective study

Evelyne Santana Girão; Bruno de Melo Tavares; Sania Alves Dos Santos; Gessica Lorena Gamarra; Camila Rizek; Roberta Cristina Martins; Lauro Vieira Perdigão Neto; Constancia Diogo; Tatiana D' Annibale Orsi; Evelyn Patricía Sanchez Espinoza; Hugo Manuel Paz Morales; Keite da Silva Nogueira; Adriane Ceshin Maestri; Icaro Boszczowski; Filipe Piastrelli; Cecilia Leite Costa; Daniely Viana Costa; Geovania Maciel; Janete Romão; Thais Guimarães; Gerly Anne de Castro Brito; Silvia Figueiredo Costa

doi:10.1016/j.anaerobe.2020.102267

Prevalence of Clostridioides difficile associated diarrhea in hospitalized patients in five Brazilian centers: A multicenter, prospective study

Anaerobe. 2020 Dec:66:102267. doi: 10.1016/j.anaerobe.2020.102267. Epub 2020 Oct 17.

Authors

Evelyne Santana Girão¹, Bruno de Melo Tavares², Sania Alves Dos Santos³, Gessica Lorena Gamarra³, Camila Rizek³, Roberta Cristina Martins³, Lauro Vieira Perdigão Neto⁴, Constancia Diogo³, Tatiana D' Annibale Orsi³, Evelyn Patricía Sanchez Espinoza⁴, Hugo Manuel Paz Morales⁵, Keite da Silva Nogueira⁵, Adriane Ceshin Maestri⁵, Icaro Boszczowski⁶, Filipe Piastrelli⁷, Cecilia Leite Costa⁸, Daniely Viana Costa⁹, Geovania Maciel⁹, Janete Romão¹⁰, Thais Guimarães², Gerly Anne de Castro Brito⁸, Silvia Figueiredo Costa⁴

Affiliations

¹ Hospital Universitário Walter Cantídio, Universidade Federal do Ceará, Fortaleza, Brazil; Divisão de Moléstias Infecciosas, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil; Hospital São José de Doenças Infecciosas, Fortaleza, Brazil. Electronic address: egirao@usp.br.
² Divisão de Moléstias Infecciosas, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
³ LIM-49, Instituto de Medicina Tropical, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
⁴ Divisão de Moléstias Infecciosas, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil; LIM-49, Instituto de Medicina Tropical, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
⁵ Hospital das Clínicas, Universidade Federal do Paraná, Curitiba, Brazil.
⁶ Divisão de Moléstias Infecciosas, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil; Hospital Alemão Oswaldo Cruz, São Paulo, Brazil.
⁷ Hospital Alemão Oswaldo Cruz, São Paulo, Brazil.
⁸ Departamento de Morfologia, Universidade Federal do Ceará, Fortaleza, Brazil.
⁹ Hospital Universitário Walter Cantídio, Universidade Federal do Ceará, Fortaleza, Brazil.
¹⁰ Hospital São José de Doenças Infecciosas, Fortaleza, Brazil.

PMID: 33080372
DOI: 10.1016/j.anaerobe.2020.102267

Abstract

Epidemiological data on CD infection (CDI) in Latin American are scarce. CDI prevalence and strains characterization were prospectively evaluated in 5 Brazilian hospitals from different regions. Prevalence rates of CDI were 15%, ranging from 0 to 37%. ST42 was the most common Sequence Type and hypervirulent strains were not identified.

Keywords: Brazilian centers; Clostridioides difficile; Prevalence; diarrhea.

Publication types

Multicenter Study

MeSH terms

Adolescent
Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents / therapeutic use
Bacterial Proteins / genetics
Bacterial Toxins / genetics
Brazil / epidemiology
Clostridioides difficile / classification*
Clostridioides difficile / drug effects
Clostridioides difficile / isolation & purification
Clostridium Infections / diagnosis
Clostridium Infections / drug therapy
Clostridium Infections / epidemiology*
DNA, Bacterial
Diarrhea / epidemiology*
Diarrhea / microbiology
Feces / microbiology
Female
Glutamate Dehydrogenase / genetics
Hospitals
Humans
Male
Middle Aged
Prevalence
Prospective Studies
Whole Genome Sequencing
Young Adult

Substances

Anti-Bacterial Agents
Bacterial Proteins
Bacterial Toxins
DNA, Bacterial
Glutamate Dehydrogenase