Candida albicans endocarditis involving a normal native aortic valve in an immunocompetent patient

BMJ Case Rep. 2020 Nov 17;13(11):e236902. doi: 10.1136/bcr-2020-236902.

Abstract

Fungal endocarditis, specifically from Candida species, is a rare but serious infection with a high mortality rate. Most cases occur in bioprosthetic or mechanical valves and are uncommon in native, structurally normal valves. When Candida endocarditis is detected and appropriate treatment is initiated earlier, there is an improvement in mortality. While the recommendation is usually to treat with a combination of surgery and antifungal medications, patient comorbidities may limit treatment options.

Keywords: clinical diagnostic tests; infections; radiology (diagnostics); tropical medicine (infectious disease); valvar diseases.

Publication types

  • Case Reports

MeSH terms

  • Administration, Intravenous
  • Aftercare
  • Aged, 80 and over
  • Antifungal Agents / administration & dosage
  • Antifungal Agents / therapeutic use
  • Aortic Valve / diagnostic imaging
  • Aortic Valve / pathology
  • Candida albicans / isolation & purification*
  • Candidiasis / complications*
  • Candidiasis / drug therapy
  • Candidiasis / microbiology
  • Echocardiography, Transesophageal / methods
  • Endocarditis / microbiology*
  • Fluconazole / administration & dosage
  • Fluconazole / therapeutic use
  • Heart Valve Diseases / microbiology
  • Humans
  • Immunocompetence
  • Male
  • Treatment Outcome
  • Ventricular Dysfunction, Left / diagnostic imaging

Substances

  • Antifungal Agents
  • Fluconazole