Somatic Nonepigenetic Mismatch Repair Gene Aberrations Underly Most Mismatch Repair-Deficient Lynch-Like Tumors

Gastroenterology. 2021 Mar;160(4):1414-1416.e3. doi: 10.1053/j.gastro.2020.11.042. Epub 2020 Nov 28.

Dutch LS-Like Study Group:
Charlotte J Dommering, Nicoline Hoogerbrugge, Mirjam M de Jong, Fonnet E Bleeker, Edward M Leter, Tom G W Letteboer, Maartje Nielsen, Rachel S van der Post, Brigit Wapstra

¹ Department of Human Genetics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.
² Department of Pathology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.
³ Department of Human Genetics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands; Department of Pathology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands. Electronic address: marjolijn.ligtenberg@radboudumc.nl.

No abstract available

Keywords: Germline Variants; Lynch Syndrome; Microsatellite Instability; Mismatch Repair Deficiency; Somatic Mutations.

Publication types