Graphene and its derivatives are promising candidates for a variety of biological applications, among which, their anti-pathogenic properties are highly attractive due to the outstanding physicochemical characteristics of these novel nanomaterials. The antibacterial, antiviral and antifungal performances of graphene are increasingly becoming more important due to the pathogen's resistance to existing drugs. Despite this, the factors influencing the antibacterial activity of graphene nanomaterials, and consequently, the mechanisms involved are still controversial. This review aims to systematically summarize the literature, discussing various factors that affect the antibacterial performance of graphene materials, including the shape, size, functional group and the electrical conductivity of graphene flakes, as well as the concentration, contact time and the pH value of the graphene suspensions used in related microbial tests. We discuss the possible surface and edge interactions between bacterial cells and graphene nanomaterials, which cause antibacterial effects such as membrane/oxidative/photothermal stresses, charge transfer, entrapment and self-killing phenomena. This article reviews the anti-pathogenic activity of graphene nanomaterials, comprising their antibacterial, antiviral, antifungal and biofilm-forming performance, with an emphasis on the antibacterial mechanisms involved.
Keywords: Antibacterial performance; Graphene; Mechanism; Microstructure; Structure.
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