Unexpected Mycoplasma hominis infection in two renal transplant recipients traced back to the same donor by whole-genome sequencing

Eur J Clin Microbiol Infect Dis. 2021 May;40(5):1097-1102. doi: 10.1007/s10096-020-04116-y. Epub 2020 Dec 23.

Abstract

Mycoplasma hominis is a common colonizer of the lower genitourinary tract. Although its clinical relevance for causing urogenital infections in immunocompetent individuals is controversial, this bacterium has been involved in severe invasive infections in allograft recipients. In this report, we describe two cases of M. hominis infection in two young renal transplant recipients within the first month post-transplant. Although at first no epidemiological link between the two cases had been suspected, whole-genome sequencing (WGS) analysis showed that both isolates were identical, highly suggestive of an origin with the common organ donor.

Keywords: Mycoplasma hominis; Renal transplant; Typing; Whole-genome sequencing (WGS).

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anti-Bacterial Agents / therapeutic use
  • Ethylene Glycols / poisoning
  • Humans
  • Kidney Transplantation / adverse effects*
  • Male
  • Mycoplasma Infections / microbiology*
  • Mycoplasma hominis / genetics*
  • Nephritis, Interstitial / complications
  • Renal Insufficiency / etiology
  • Renal Insufficiency / surgery
  • Tissue Donors
  • Transplant Recipients*
  • Whole Genome Sequencing*
  • Young Adult

Substances

  • Anti-Bacterial Agents
  • Ethylene Glycols
  • diethylene glycol